mRNA mixtures designed by Hotz et al. encoding Interleukin-12 (IL-12) single chain, type I Interferon alpha (IFN-α), granulocyte–macrophage colony-stimulating factor (GM-CSF), and IL-15 sushi (sushi structural domain of the IL-15 receptor α chain fused to IL-15), altered the intra-tumor microenvironment, enhanced CD4+ and CD8+ T cell immunity in mice, and improved survival in tumor-tested mice [129]. Here, CSF2 is linked to neoplasm.