In the Bivariate logistic analysis model, fourteen (14) factors were found to be associated with having depression: Marital status, education level, occupation, monthly income, residency area, CD4 level, stigma, social support, opportunistic infection, HIV/AIDS stage, treatment type, treatment adherence, HIV status disclosure, and substance use (Tables 4 and 5). This evidence concerns the gene CD4 and major depressive disorder.