From the results, we noticed that tumor cells highly expressed AUP1 significantly correlated with proliferation marker (MCM2, MCM6), PI3K-AKT-MTOR pathway (Akt1, TSC1, mTOR, Foxo1), and autophagy signaling (Atg3, Atg4B, Atg4D, Atg7, Atg9A, Atg16L1) in IDH wildtype tumor cells (Table 1). The gene discussed is ATG4B; the disease is neoplasm.