Similarly, in the context of the IDH mutant astrocytoma, the tumor with higher AUP1 was significantly correlated with PI3K-AKT-MTOR pathway (EGFR, PDGFRA, TSC2, MTOR), and autophagy signaling (ATG4B) (Table 2). The gene discussed is TSC2; the disease is astrocytoma (excluding glioblastoma).