TGFBR2 and autoimmune thrombocytopenic purpura: However, the present study revealed an elevated incidence of 13.6% of two common TGFBR2 variants in elderly primary ITP patients who displayed senescence related Treg dysfunction, indicating potential genetic susceptibility to develop autoimmune diseases in their middle to late adulthood instead of earlier ages, as well as impaired immune tolerance to benefit from corticosteroids.