In particular, BM microenvironment of patients with same malignancy (see AML patients) and subjected to similar conditioning regimen (myeloablative) seems to act in a similar way on HSPC methylation status, while BM of patients with different malignancy (see HL-CLL-MM) and same conditioning regimen (reduced) induced, an early different HSPC methylation. The gene discussed is PSMA7; the disease is Miyoshi myopathy.