Glut-1 expression was reduced in CD8+TM under mdivi-1 treatment (Fig. 8f), suggesting that inhibition of mitophagy may reverse dysregulated glucose metabolism and normalize memory differentiation in CD8+Tc. Collectively, these results demonstrate that pharmacological inhibition of mitophagy may restore metabolic dysregulation to improve the efficacy of the CD8+Tc response in COVID-19. The gene discussed is CD8A; the disease is COVID-19.