CD8A and COVID-19: Given that healthy, functional SARS-CoV-2-specific CD8+Tc are associated with milder, recovered, and convalescent COVID-19 patients79, targeting the hypoxia/anaerobic glycolysis may potentially improve the function of SARS-CoV-2 antigen-specific CD8+Tc during re-exposure to viral antigens, and rescue impaired memory cell differentiation.