The symptoms of bleomycin-induced IP mouse models deficient in Nuclear factor-erythroid 2-related factor 2 (NRF2: in vivo antioxidant system regulatory transcription factor)12,13 and in vivo antioxidant enzymes, such as Extracellular superoxide dismutase (EC-SOD)6,14 and catalase15, were worse than those of the wild-type IP mouse models. Here, NFE2L2 is linked to incontinentia pigmenti.