ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blockers; BB, beta-blockers; CCB, calcium channel blockers; CKD, chronic kidney disease; CVD, cardiovascular disease; DBP, diastolic blood pressure; DM, diabetes mellitus; ESRD, end-stage renal disease; RI, renin inhibitor; SBP, systolic blood pressure; TZD, thiazide diuretics; SPR, spironolactone. The gene discussed is REN; the disease is stage 5 chronic kidney disease.