A gene-set analysis identified no biological process significantly associated with the 11 genes, but these genes are involved in IgG glycosylation (TAB1, MGAT3, and CACNA1I) and Response to methotrexate in juvenile idiopathic arthritis (CACNA1I and APOBEC3C) reported by GWAS catalog (see Fig. 4). The gene discussed is MGAT3; the disease is juvenile idiopathic arthritis.