TGFA and urokinase-type plasminogen activator measurement: By comparing 48 cytokine levels of UPA group and control group (Table2), we obtained 16 cytokines showing statistical significance, among which IP-10, CXCL9 and RANTES were higher in APA group than in control group(p < 0.05), while the other 13 cytokines including IL-1a, IL-1b, IL-2, IL-5, IL-8, MCP-1, MIP-1b, PDGF- AB-BB, TGFa, TNFb, VEGF-A, EGF and IL-17A were lower in UPA group than in control group(p < 0.05).