Among patients without LMD, 4 had ductal histology (80.0%), and 1 had lobular (20.0%); 1 had ER+/HER2− disease (20.0%), 3 had ER+/HER2+ disease (60.0%), and 1 had ER−/HER2+ disease. Here, ESR1 is linked to Langer mesomelic dysplasia.