To further improved the precision of targeting, attempts have been made to combine tumor-specific promoter-derived transcriptional targeting with transductional targeting (through viral capsid incorporation of antihuman carcinoembryonic antigen single variable domains).397 The results showed that employment of a single variable domain genetically incorporated into an AdV fiber increased specificity of infection and efficacy of replication of single variable domain-targeted oncolytic AdV. This evidence concerns the gene CEACAM5 and neoplasm.