It showed an inhibitory effect on tumor angiogenesis in the animal model of human colorectal cancer.373 Specifically, IL-24 is an effective anti-angiogenic cytokine, which can inhibit angiogenesis and induce apoptosis of tumor cells.374 IL-24 gene was inserted into AdV, termed HE1B55D-RGD-IL-24.375 On this basis, the additional anti-angiogenic arrested fragment was inserted into AdV to construct HE1B55D-RGD. The gene discussed is IL24; the disease is colorectal cancer.