ASPSCR1 and alveolar soft part sarcoma: ASPSCR1::TFE3 also upregulates genes important for angiogenesis and tumor metastasis, such as PDGFB, ANGPTL2, and GPNMB17,24,25, suggesting that ASPSCR1::TFE3 plays a central role in the angiogenesis characteristic of ASPS.