Previous studies identified numerous ASPSCR1::TFE3 targets that are involved in growth signaling, lysosomal functions, autophagy, and angiogenesis in both ASPS and fusion-positive renal cell carcinoma, with the latter exhibiting a vascular structure similar to that of ASPS21,22,24,25,36. The gene discussed is TFE3; the disease is hereditary clear cell renal cell carcinoma.