T3 induced apoptosis and G2/M cell cycle arrest in human A2780 and HCT116 cells by targeting CLK.131 Mechanically, T3 application modified AS events in cancer by decreasing the expression of the anti-apoptotic forms of cIAP1, cIAP2, XIAP, cFLIP, and Mcl-1.132 Meanwhile, T3 synergistically induced apoptosis together with Bcl-xL/Bcl-2 inhibitor in human HCT116 and A2780 cancer cells.132. Here, CLK1 is linked to cancer.