Osteoarthritis (OA) is a disease characterized by the formation of osteophytes, cartilage degradation, and synovial inflammation.70 CLK2 and DYRK1A participate in OA through the Wnt pathway without modulating β-catenin activity, resulting in inflammatory cytokine production and cartilage catabolic enzyme expression.71,72 In addition, CLK2 inhibition suppressed cartilage catabolic enzyme expression and induced early chondrocyte differentiation in human mesenchymal stem cells (hMSCs).71 This finding reveals a novel role of CLK2 in promoting OA. This evidence concerns the gene CLK2 and osteoarthritis.