CLK1 was expressed at levels 10 to 30% higher in gastric tumor samples compared to normal gastric tissues.40 In a phosphor-proteomic analysis study, CLK1 and its related splicing machinery pathway were shown to be the most important regulators in gastric cancer.40 CLK1 was overexpressed in gastric cancer tissues and the inhibition of CLK1 resulted in the suppression of cell proliferation, migration, and invasion.40 These findings indicate that CLK1 plays an important role in gastric cancer progression. This evidence concerns the gene CLK1 and gastric neoplasm.