CLK3 and hepatocellular carcinoma: CLK3 was also markedly upregulated and closely associated with hepatocellular carcinoma (HCC) TNM stages and patient prognosis.125 Functional analysis revealed that CLK3 promoted Wnt 3a transcription and activated Wnt/β-catenin cascades, resulting in increased HCC cell proliferation, migration, and invasion in vitro; additionally, animal experiments showed that CLK3 also increased tumor development in vivo.