MBNL1 and myotonic dystrophy type 1: A previous study found that mice with a genetic reduction of both MBNL1 and MBNL2 proteins in muscle tissue develop DM1-like features that are more severe than absence of either MBNL1 or MBNL2 protein in isolation, supporting a model that compound loss of MBNL proteins is a critical step in DM1 pathogenesis26.