LGI1 and viral encephalitis: Previous studies showed simultaneous occurrence of both epitope-specific LGI1 antibodies in patients with LGI1 encephalitis with an increased ratio of LRR-specific IgG.20 From our data and other reports investigating epitope-specific effects of LGI1 mAbs,15,21,42 LRR-specific IgG might be more effective in inducing hyperexcitability and possibly leading to seizure initiation.