NFKB1 and inborn error of immunity: Functional enrichment analyses using the Kyoto Encyclopedia of Genes and Genomes pathways (61, 62) revealed a significant enrichment of several major signaling pathways, including cytokine-cytokine receptor interaction, primary immunodeficiency, NF-κB signaling pathway, chemokine signaling pathway, and TLR signaling pathway (Fig. 6D).