E2F7 cooperates with transcriptional activator RUNX family transcription factor 1 (RUNX1) that is recruited by core-binding factor subunit beta (CBFB) to transactivate integrin subunit alpha (ITGA2), ITGA5, and neurotrophic receptor tyrosine kinase 1 (NTRK1), which consequently promotes NPC progression. The gene discussed is ITGA5; the disease is nasopharyngeal carcinoma.