The liver of HFD+shSTK38 mice was less pale as compared to HFD mice (Fig. S5B) To explore if STK38 knockdown can rescue diet-induced hepatic insulin resistance, we explored the AKT phosphorylation at S473 in the liver tissue in insulin-stimulated mice and found enhanced AKT phosphorylation at S473 in STK38 knockdown mice as compared to HFD mice with increased insulin receptor at Y1150 residue (Fig. 5F). The gene discussed is INS; the disease is Insulin resistance.