AKT1 and Insulin resistance: The liver of HFD+shSTK38 mice was less pale as compared to HFD mice (Fig. S5B) To explore if STK38 knockdown can rescue diet-induced hepatic insulin resistance, we explored the AKT phosphorylation at S473 in the liver tissue in insulin-stimulated mice and found enhanced AKT phosphorylation at S473 in STK38 knockdown mice as compared to HFD mice with increased insulin receptor at Y1150 residue (Fig. 5F).