Taken together, the food-derivedbioactive peptides could be apotential dietary supplement to help manage obesity and diabetes byintervening in the activities of enzymes, such as DDP-IV and α-glucosidase,and by modulating inflammation, lipid metabolism, and insulin resistance.However, the available data on the stability, kinetics, and bioavailabilityof these bioactive peptides are scarce. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.