INS and obesity due to melanocortin 4 receptor deficiency: T2D, also called noninsulin dependent DM,involves an imbalance in insulin production and blood glucose uptake.4 Inadequate treatments of DM can result in seriouscomplications, such as cardiovascular diseases, nephropathia, diabeticretinopathy, amputation, and nerve damage.5 Both obesity and DM are strongly associated with an unhealthy dietsuch as a high-fat diet (HFD) and a high-sugar carbohydrate diet fora long time.