Mice with the average tumor volume more than 200 mm3 were considered as not responding to the ICI therapy with anti–PD-L1 antibodies and were given: (i) DMSO control + anti-mouse PD-L1 antibody (6 mg/kg) or (ii) the combination of PIK-93 (60 mg/kg) + anti-mouse PD-L1 antibody (6 mg/kg; n = 4 mice for each group). The gene discussed is CD274; the disease is neoplasm.