Preliminary studies of Apigenin and similar flavonoids have revealed that these effects may be mediated by immune cell response involvement through the modulation of multiple signaling pathways including PI3K/AKT, MAPK/ERK, JAK/STAT, NF-κB and Wnt/β-catenin that play key roles in the development and progression of cancer [22, 24, 25]. Here, NFKB1 is linked to cancer.