However, long-term inhibition of TNFR1 and TNFR2 signaling enhances tau accumulation and the formation of pathological Aβ (Zhao et al., 2020) The cause of AD progression is not only dependent on soluble Aβ oligomers, which in many studies are considered to be precursors of neurodegeneration, but also on ongoing neuroinflammation and other factors mentioned. This evidence concerns the gene MAPT and Alzheimer disease.