S100A2, for example, was firstly found to act as a tumor suppressor gene, having a downregulated expression in skin, lung, kidney and prostate tumors.[6–8] On the other hand, S100A2 was found to have an upregulation in some cancer types as well, including pancreatic cancer, gastric cancer and epithelial ovarian cancer. The gene discussed is S100A2; the disease is prostate neoplasm.