S100A2, for example, was firstly found to act as a tumor suppressor gene, having a downregulated expression in skin, lung, kidney and prostate tumors.[6–8] On the other hand, S100A2 was found to have an upregulation in some cancer types as well, including pancreatic cancer, gastric cancer and epithelial ovarian cancer. This evidence concerns the gene S100A2 and familial pancreatic carcinoma.