it is generally accepted that SOX9 promotes the formation of tumors by regulating cell cycle progression and cell proliferation.[31] However, there are also opposite results showing that SOX9 functioned as a tumor suppressor.[32,33] LY86 encodes protein lymphocyte antigen 86, which also known as MD-1, is a secreted glycoprotein. The gene discussed is PROS1; the disease is neoplasm.