MGMT and metastatic malignant neoplasm in the lymph nodes: Furthermore, Theocharis et al[14] showed that high expression of MGMT is significantly associated with a clear tumor morphology, reduced depth of invasion, and no lymph node metastasis, suggesting that MGMT may be involved in the early stages of active tongue squamous cell carcinoma, play a protective role in the body, and inhibit tumor formation and development.