MGMT and head and neck squamous cell carcinoma: Aberrant methylation of the MGMT promoter is significantly associated with the risk of HNSCC[28]; however, researchers have different opinions about whether hypermethylated MGMT is a prognostic biomarker.[15-17,25,29] Zuo et al[25] studied 93 patients with HNSCC, and Scesnaite et al[15] studied 286 patients with salivary gland cancer.