In the current case, the positive expression of human melanoma black-45, S-100, and Melan-A diagnosed the tumor as a melanocytic neoplasm, which was consistent with previous studies.[7–9] The difference between malignant melanoma and melanocytoma lies in the mitotic activity of cells, nuclear abnormalities, and the degree of melanin granule proliferation. Here, MLANA is linked to melanocytic neoplasm.