WASL and rectal cancer: In rectal cancer, LIM and SH3 protein 1 (LASP1) interact with N-WASP to activate the Arp2/3 complex, which subsequently promotes actin polymerization and facilitates colorectal cancer invasion/metastasis.[34] In conclusion, since phosphorylation of N-WASP by multiple kinases can regulate the activity of the Arp2/3 complex, targeting these phosphorylation events may lead to the development of new anti-invasive therapeutic options for cancer.