In another study, Rada et al[54] discovered that Runt-related transcription factor-1 (RUNX1) was overexpressed in vascular-selective colorectal cancer liver metastasis (CRCLM) tumor cells and that being an upstream positive regulator of the Arp2/3 complex expression level could drive cancer cell motility through the Arp2/3 complex to achieve vascular coexistence, implying that ARP2/3 is a key mediator of vascular coexistence in CRCLM14. Here, ACTR2 is linked to neoplasm.