They have been shown to consist of protrusions assembled by actin that adhere to the cell membrane and facilitates the advancement of cell, and the initial step in the migration and invasion of cancer cells is the extension of the protrusions in the direction of cell movement.[3] In reality, Arp2/3 complex-mediated actin polymerization plays an irreplaceable role in the development of both plate-like and invasive pseudopods. This evidence concerns the gene ACTR2 and cancer.