ACTR2 and cancer: However, some phosphorylation events occurring in NPFs affect the ability of the VCA domain to bind and activate the Arp2/3 complex, which in turn regulates the formation of cellular pseudopods and the invasion and migration of cancer cells.[6,7] In conclusion, the Arp2/3 complex has lately become demanding issue in cancer invasion and metastasis because it is necessary in a number of biological processes, including podocyte and platelet cell production, and offers invasive and migratory qualities to cells.