Pancreatic cancer (PC) is the most lethal neoplastic epithelial tumor, with a 5-year overall survival rate of about 10%, and is anticipated to overtake lung cancer as the second biggest cause of cancer-related deaths by 2024.[46] Rauhala et al[47] discovered that ARPC3 and ARPC4 were the most highly expressed subunits of the Arp2/3 complex in pancreatic cancer and that silencing of Arp complex subunits, particularly ARPC4, significantly reduced pancreatic cancer cell migration, implying that the Arp2/3 complex plays a key role in pancreatic cancer cell invasion and migration. Here, ACTR2 is linked to pachyonychia congenita.