ACTR2 and neoplasm: Invadopodia are a type of actin-rich cell protrusion that protrudes ventrally from the plasma membrane and has invasive, sticky, and matrix-degrading properties, as well as being the point of convergence for several signals that regulate tumor cell invasion and migration.[27] Yamaguchi et al[28] used RNA interference and other techniques to demonstrate that the Arp2/3 complex is essential for invasive pseudopod production in a study on the process of invasive pseudopod generation.