Through various bioinformatics analysis methods, Huang et al[59] discovered that upregulation of Arp2/3 complex expression in hepatocellular carcinoma tissues was closely associated with poorer overall survival in hepatocellular carcinoma patients, and further suggested that the Arp2/3 complex’s Arp2, ARPC2, and ARPC5 subunits could be independent risk factors for survival in hepatocellular carcinoma patients. The gene discussed is ARPC2; the disease is hepatocellular carcinoma.