The function of the Arp2/3 complex in mediating actin polymerization requires not only its own phosphorylation modification but also activation or promotion by various nucleation-promoting factors, such as cortactin, WASP (Wiskott-Aldrich syndrome protein) family proteins, WAVE (The WASP family verproline-homologous protein), etc., all of which may be potential targets for anti-invasive cancer therapy. This evidence concerns the gene WASF1 and cancer.