ACTR3 and digestive system neoplasm: Gastric cancer is one of the most prevalent tumors of the digestive system, with the fifth highest incidence (5.6%) and fourth highest death rate (7.7%) among cancers globally, posing a serious threat to human health.[50] In a study on gastric cancer, Zheng et al[51] found that the expression of Arp2 and Arp3 proteins were both significantly higher in gastric cancer than in gastritis by immunohistochemistry and further suggested that there was a positive correlation between the expression of Arp2 and Arp3 proteins and the size, depth of infiltration, and venous infiltration of tumor tissue.