HLA-A and pancreatic adenocarcinoma: That is to say, the PAAD patients carrying HLA-A02 supertype rather than other HLA-A supertypes appeared to be more prone to have downregulated HLA-A, consequently facilitating immune evasion owing to lessened expression of HLA and impaired antigen presentation in cancer cells21–23, which was likely a contributory cause for short-term recurrence of HLA-A02+B62+B44− individuals infrequently observed in PAAD LTSs.