CD274 and neoplasm: Several strategies have been reported to prime the tumor to facilitate the effectiveness of ICIs, including chemotherapy,[37, 38] toll‐like receptor agonist,[39] STING1 agonist,[40] and radiotherapy.[41] The main finding of our study is that ferroptotic stress in HNSCC cells upregulates PD‐L1, which provides the potential to prime HNSCC to potentiate the efficacy of ICIs.