Several strategies have been reported to prime the tumor to facilitate the effectiveness of ICIs, including chemotherapy,[37, 38] toll‐like receptor agonist,[39] STING1 agonist,[40] and radiotherapy.[41] The main finding of our study is that ferroptotic stress in HNSCC cells upregulates PD‐L1, which provides the potential to prime HNSCC to potentiate the efficacy of ICIs. Here, STING1 is linked to head and neck squamous cell carcinoma.