Several strategies have been reported to prime the tumor to facilitate the effectiveness of ICIs, including chemotherapy,[37, 38] toll‐like receptor agonist,[39] STING1 agonist,[40] and radiotherapy.[41] The main finding of our study is that ferroptotic stress in HNSCC cells upregulates PD‐L1, which provides the potential to prime HNSCC to potentiate the efficacy of ICIs. The gene discussed is STING1; the disease is neoplasm.