Since the entry of substances through ASGPR occurs via clathrin‐mediated endocytosis, ASGPR exhibits a high affinity for carbohydrates, particularly Gal, N‐acetylgalactosamine (GalNAc), and glucose.[33] Gal is a representative target of ASGPR in HCC which has been extensively exploited for targeted imaging.[34] For example, a fluorescent probe (DCDHF‐βgal) for in vivo imaging of HCC was developed leveraging the NIR fluorophore dicyanomethylenedihydrofuran (DCDHF).[35] The tumor‐specific targeting ability of DCDHF‐βgal was investigated using a HepG2 tumor‐bearing xenograft mouse model. This evidence concerns the gene ASGR1 and hepatocellular carcinoma.