Since Tf is a hydrophilic glycoprotein, when amphiphilic Tf‐glycidyl hexadecyl dimethylammonium chloride (GHDC) is prepared, a liposome formed with Tf on the outer surface can interact and facilitate uptake by TfR (Figure 3c).[51] For example, a Dox‐loaded polycarbonate‐based nanoparticle (Tf‐Ps‐Dox) that could be guided by Tf was developed.[52] Tf‐Ps‐Dox not only effectively accumulated in the SMMC‐7721 tumor‐bearing mice with the help of Tf targeting ligand but also achieved desirable therapeutic efficacy in an orthotopic SMMC‐7721 tumor‐bearing mouse model. This evidence concerns the gene TF and neoplasm.