In contrast to other methodological approaches used in the mentioned studies, Min et al. (1) induced EMT in ESCC cell lines using a GSK-3 inhibitor (SB-415286), which resulted in significant downregulation of E-cadherin and upregulation of vimentin and Snail mesenchymal genes. The gene discussed is SNAI1; the disease is esophageal squamous cell carcinoma.