When comparing the data, one could observe that high values of these biomarkers are associated with patients with periodontitis, because the mean differences were: IL-6: 37.27 (CI: 21.70, 42.84); Nitric oxide: 8.36 (CI: 5.10, 11.62); IL-1B: 190.62 (CI: 105.28, 275.95), TNF-α: 3.59 (CI: 1.16, 6.02) and osteoprotegerin (CI: 0.24, 1.76). Here, TNF is linked to periodontitis.