The other biomarkers were not statistically significant when related to periodontitis: calprotectin (MD = 2.30, CI: -91.79, 96.38, P = 0.96), ICTP (MD = 0.26, CI: -9.24, 9.75, P = 0.96), IgA (MD = 33.90, CI: -55.86, 123.66, P = 0.46), IL-4 (MD = 187.25, CI: -35871711.76, 35875456.27, P = 1.00), IL-10 (MD = 3948.05, CI: -152801135.56, 152809031.66, P = 1.00), IL-13 (MD = -7622.65, CI: -1910525421.50, 1910510176.19, P = 1.00), MMP-8 (MD = 1704.03, CI: -728.80, 4136.86, P = 0.17), MMP-9 (MD = 688.90, CI: -5077007.25, 5078385.06, P = 1.00). The gene discussed is IL4; the disease is periodontitis.