TNF and periodontitis: In the course of periodontitis, chemokines such as chemokine (C-X-C motif) ligand 1 (CXCL-1), C-X-C motif chemokine ligand 8 (CXCL-8), C-C motif chemokine ligand 5 CCL-5 and cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6 are present in the inflammatory process of periodontitis and are responsible for recruiting T cells, neutrophil chemotaxis and increased permeability of small blood vessels (5)