The most affected pathways in HiB-downregulated genes were cellular signaling (Rap1 signaling, cGMP–PKG signaling, thyroid hormone signaling, PI3K–Akt signaling and AGE–RAGE signaling in diabetes) and cytoskeletal dynamics (focal adhesion, regulation of actin cytoskeleton, Rap1 signaling) (Figure 1G). This evidence concerns the gene RENBP and diabetes mellitus.