Cell states related to the respective processes were segregated into their own distinct zones, the regions being mutually exclusive.[155] In the case of pancreatic neoplasms, spatial transcriptomics profiling directly confirmed the initial annotations of pancreatic intraepithelial neoplasia constructed with scRNA‐seq data.[156] Furthermore, receptor‐ligand analyses suggested the interaction of the T cell immunoreceptor with Ig and ITIM domains (TIGIT) receptor of lymphocytes with Nectinligands, TIGIT being highly expressed in tumor cells. This evidence concerns the gene TIGIT and pancreatic neoplasm.