Moreover, pVAX-LAMP1-CCHFV-NP could most effectively protect mice from CCHFV tecVLPs infection, and pVAX-LAMP1-CCHFV-Gc also showed a certain protection from CCHFV tecVLPs infection in mice, but the protective efficacy was less than that of pVAX-LAMP1-CCHFV-NP. Here, LAMP1 is linked to infection.