After performing cross-comparative analysis with Jvenn, a reliable web portal for Venn analysis, 17 common DEGs from the AKI, CKD, and SARS-CoV-2 datasets were identified, including HBD, HBB, TANK, RNF6, TAB2, WTAP, PNRC1, ING3, TNFAIP8, S1PR1, SEC24A, NRIP1, MARCKS, BHLHE40, DUSP6, EIF2AK2, and RASGRP1. The gene discussed is RNF6; the disease is acute kidney injury.