INS and Insulin resistance: In fact, our computational projections suggested that to alleviate insulin resistance, a combined approach of anti-inflammatory therapy together with inhibitors of intracellular ceramide signaling is needed, because anti-inflammatory actions would control the inflammation of adipocytes as well as the immune system, particularly Th17, Th1 and M1 populations, while ceramide inhibitors would favor the sensitization of insulin-resistant adipocytes.