Among 44 DEGs that were unique to the COVID-19(+) TV group (Figure 2B), genes involved in responses to viral infection, such as the interferon regulatory factor 7 (IRF7) transcription factor and interferon-induced with helicase C domain 1 (IFIH1) that encodes the cytosolic nucleic acid sensor MDA-5, were identified among the top TV-specific up-regulated genes compared to COVID-19(+) PU and COVID-19(-) PU groups. The gene discussed is IRF7; the disease is COVID-19.