In comparison to the COVID-19(-) PU controls, genes highly expressed in the TV group fell into categories that included neutrophil dysfunction (CD274, PADI2), inhibition of B and T cell responses (CD22, IRF4, ORAI1), and upregulation of pro-inflammatory response pathways (CARD8, MAPK7, IRF7, IFIH1). This evidence concerns the gene CARD8 and COVID-19.