YWHAZ and melanoma: Figure 4F also confirmed that the mortality of the CSIRG high-risk melanoma patients increased. The expression of the five hub CSIRGs (EIF4A2, MCL1, NUP188, STAT1, and YWHAZ) in the high- and low-risk groups is shown in Figure 4G. The results showed that EIF4A2, MCL1, and STAT1 were downregulated in the high-risk group, while NUP188 and YWHAZ were upregulated in the high-risk group (Figure 4G).