Taking together with the previous studies, five patients with anti-mGluR5 encephalitis had additional antibodies and all showed atypical symptoms: the patient with SOX1 antibodies had progressive ophthalmoplegia (7), the patient with Recoverin antibodies had visual deficits and confirmed retinopathy, the patient with NMDAR+AMPAR antibodies had refractory status epilepticus, the patient with NMDAR+MOG antibodies had cerebral cortical encephalitis (11), and the patient with LGI1 antibodies had faciobrachial dystonic seizures (12). The gene discussed is GRM5; the disease is encephalitis.