NF2 mutant meningiomas are more likely to be characterized by atypical histology and genetic instability38,42,43 and have been identified in multiple case reports of meningioma metastasis.44,45 Recent genomic studies have demonstrated that meningiomas with mutations in NF2 were more likely to recur than those with KLF4, POLR2A, or SMARCB1 mutations.6,7 Lastly, methylation profiling has been shown to be a stronger indicator of recurrence risk than classic prognosticators such as WHO grade.46 Here, POLR2A is linked to meningioma.