Furthermore, we also observed increased plasma IL-6 in TLE patients compared to extratemporal lobe epilepsy (XLE) patients, suggesting that the epilepsy type is important for determining seizure-induced IL-6 production (Alapirtti et al., 2018), and recently, we observed that IL-6 plasma levels are modified by hippocampal sclerosis (HS) and its lateralization in drug-resistant temporal lobe epilepsy (accepted). This evidence concerns the gene IL6 and histiocytic sarcoma.