TP53 and neoplasm: Multiple studies suggest that p53 downregulates the expression of SLC7A11 as demonstrated in polymorphic mutants of p53, and the mechanism of p53-mediated tumor suppression is governed by the inhibition of SLC7A11 function, conferring resistance to ferroptosis (Jiang et al., 2015b; Jennis et al., 2016; Wang et al., 2016).