PTTG1 and colorectal cancer: It has also been implicated in the migration and invasion of cancer cells via the regulation of MMP-2 and MMP-9 in several cancers, PTTG1 in colorectal cancer, and YAP1 in triple negative breast cancer (Wang et al., 2008, 1; Zheng et al., 2015, 1; Sun et al., 2020).