Another study found AR inhibitors enzalutamide and bicalutamide upregulated CCL2 via STAT3 in PCa cells, leading them to propose the use of CCL2/CCR2 or STAT3 inhibitors in combination with AR inhibitors to block the pro-tumoral effects of ADT-induced CCL2 (255). The gene discussed is CCR2; the disease is posterior cortical atrophy.