Additionally, it has been shown in osteosarcoma, a bone cancer arising from malignant transformation of osteoblasts, that tumor cell-derived CXCL8 can upregulate MSC expression of CXCL8, which then increases osteosarcoma cell expression of CXCL8, creating a positive feedback loop driving tumor progression (180). This evidence concerns the gene CXCL8 and bone cancer.