A recent study reported that SETD2 could indirectly methylate non-histone substrates, loss of SETD2 increases protein translation-related gene expression and decreases eEF1A1 K165me3 and K318me1 in ccRCC, but SETD2 is associated with eEF1A1 methylation indirectly, SET domain of SETD2 regulated the expression of EEF1AKMT2 and EEF1AKMT3, EEF1AKMT3 methylates eEF1A1 on lysine 165 and EEF1AKMT2 methylates eEF1A1 on lysine 318 (109). The gene discussed is EEF1AKMT2; the disease is nonpapillary renal cell carcinoma.