There were no significant differences between the two groups of patients in age, sex, MM type, D-S stage, ISS stage, high-risk CA rate, smoking and alcohol consumption history, history of hypertension, coronary heart disease, diabetes mellitus, and stroke, baseline CRP, hemoglobin, BNP, creatine, albumin, uric acid, β2-MG, GFR, baseline high level of office blood pressure rate, LVEF, LVMI, first-line therapy regimens, and combined CV-related drugs. This evidence concerns the gene NPPB and stroke disorder.