Studies have found that peroxisome proliferative activated receptor gamma coactivator 1 alpha (PGC1α) and phospholipase C like 1 (PLCL1) mediated cellular browning by regulating uncoupling protein 1 (UCP1) level could promote tumor “slimming” and inhibit tumor progression (125, 126). Here, PPARGC1A is linked to neoplasm.