In the condition of inflammation, TRPV1 channels are also activated by various pro-inflammatory factors, such as prostaglandins, serotonin (5-HT), bradykinin, histamine, CGRP α, tumor necrosis factor α (TNFα), and etc., (Iftinca et al., 2021), which all contribute to the occurrence of neuralgia. This evidence concerns the gene TNF and neuralgia.